USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: CATD_HUMAN USC-OGP 2-DE database:  CATD_HUMAN CATD_HUMAN General information about the entry View entry in simple text format Entry name CATD_HUMAN Primary accession number P07339 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Cathepsin D; EC=3.4.23.5; Contains: RecName: Full=Cathepsin D light chain; Contains: RecName: Full=Cathepsin D heavy chain; Flags: Precursor;. Gene name Name=CTSD Synonyms=CPSD Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1261: pI=5.60; Mw=29778 SPOT OGP-1276: pI=5.55; Mw=27445 Cross-references UniProtKB/Swiss-Prot P07339; CATD_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CATD_HUMAN Primary accession number P07339 Secondary accession number(s) Q6IB57 Sequence was last modified on  April 1, 1988 (version 1) Annotations were last modified on  March 15, 2017 (version 202) Name and origin of the protein Description RecName: Full=Cathepsin D; EC=3.4.23.5; Contains: RecName: Full=Cathepsin D light chain; Contains: RecName: Full=Cathepsin D heavy chain; Flags: Precursor; Gene name Name=CTSD Synonyms=CPSD Encoded on Name=CTSD; Synonyms=CPSD Keywords 3D-structure; Alzheimer disease; Aspartyl protease; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Neurodegeneration; Neuronal ceroid lipofuscinosis; Polymorphism; Protease; Reference proteome; Secreted; Signal; Zymogen. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M11233; AAB59529.1; -; mRNA EMBL X05344; CAA28955.1; -; mRNA EMBL M63138; AAA51922.1; -; Genomic_DNA EMBL M63134; AAA51922.1; JOINED; Genomic_DNA EMBL M63135; AAA51922.1; JOINED; Genomic_DNA EMBL M63136; AAA51922.1; JOINED; Genomic_DNA EMBL M63137; AAA51922.1; JOINED; Genomic_DNA EMBL CR456947; CAG33228.1; -; mRNA EMBL BT006910; AAP35556.1; -; mRNA EMBL BT020155; AAV38957.1; -; mRNA EMBL BC016320; AAH16320.1; -; mRNA EMBL L12980; AAA16314.1; -; Genomic_DNA EMBL S74689; AAD14156.1; -; Genomic_DNA EMBL S52557; AAD13868.1; -; Genomic_DNA CCDS CCDS7725.1; -; . PIR A25771; KHHUD; . RefSeq NP_001900.1; NM_001909.4; . UniGene Hs.654447; -; . PDB 1LYA; X-ray; 2.50 A; A/C=65-161 B/D=170-410 PDB; 1LYB; X-ray; 2.50 A A/C=65-161 B/D=170-410; PDB; 1LYW; X-ray 2.50 A A/C/E/G=65-161; B/D/F/H=170-410; PDB; 4OBZ X-ray 2.90 A; A/C=60-162; B/D=170-412; PDB 4OC6 X-ray; 2.64 A; A=60-162; B=170-412 PDB 4OD9; X-ray; 1.90 A; A/C=60-162 B/D=170-412 PDBsum; 1LYA; -; . PDBsum 1LYB; -; . PDBsum 1LYW; -; . PDBsum 4OBZ; -; . PDBsum 4OC6; -; . PDBsum 4OD9; -; . ProteinModelPortal P07339; -; . SMR P07339; -; . BioGrid 107889; 45; . DIP DIP-43906N; -; . IntAct P07339; 21; . MINT MINT-3005628; -; . STRING 9606.ENSP00000236671; -; . BindingDB P07339; -; . ChEMBL CHEMBL2581; -; . DrugBank DB03028; 1h-Benoximidazole-2-Carboxylic Acid; . DrugBank DB07542; 5-AMINO-6-CYCLOHEXYL-4-HYDROXY-2-ISOBUTYL-HEXANOIC ACID; . DrugBank DB00030; Insulin Human; . DrugBank DB00071; Insulin Pork; . DrugBank DB03096; N-Aminoethylmorpholine; . DrugBank DB02216; S-Methylcysteine; . GuidetoPHARMACOLOGY 2345; -; . MEROPS A01.009; -; . iPTMnet P07339; -; . PhosphoSitePlus P07339; -; . SwissPalm P07339; -; . BioMuta CTSD; -; . DMDM 115717; -; . DOSAC-COBS-2DPAGE P07339; -; . REPRODUCTION-2DPAGE IPI00011229; -; . SWISS-2DPAGE P07339; -; . UCD-2DPAGE P07339; -; . EPD P07339; -; . PaxDb P07339; -; . PeptideAtlas P07339; -; . PRIDE P07339; -; . TopDownProteomics P07339; -; . DNASU 1509; -; . Ensembl ENST00000236671; ENSP00000236671; ENSG00000117984; . GeneID 1509; -; . KEGG hsa:1509; -; . CTD 1509; -; . DisGeNET 1509; -; . GeneCards CTSD; -; . GeneReviews CTSD; -; . H-InvDB HIX0009359; -; . HGNC HGNC:2529; CTSD; . HPA CAB000109; -; . HPA HPA003001; -; . MalaCards CTSD; -; . MIM 116840; gene; . MIM 610127; phenotype; . neXtProt NX_P07339; -; . OpenTargets ENSG00000117984; -; . Orphanet 228337; CLN10 disease; . PharmGKB PA27029; -; . eggNOG KOG1339; Eukaryota; . eggNOG ENOG410XNV7; LUCA; . GeneTree ENSGT00760000118929; -; . HOGENOM HOG000197681; -; . HOVERGEN HBG000482; -; . InParanoid P07339; -; . KO K01379; -; . OMA KVERQVF; -; . OrthoDB EOG091G0JP7; -; . PhylomeDB P07339; -; . TreeFam TF314990; -; . BioCyc MetaCyc:HS04183-MONOMER; -; . BRENDA 3.4.23.5; 2681; . Reactome R-HSA-1442490; Collagen degradation; . Reactome R-HSA-2022377; Metabolism of Angiotensinogen to Angiotensins; . Reactome R-HSA-2132295; MHC class II antigen presentation; . Reactome R-HSA-6798695; Neutrophil degranulation; . EvolutionaryTrace P07339; -; . GeneWiki Cathepsin_D; -; . GenomeRNAi 1509; -; . PMAP-CutDB P07339; -; . PRO PR:P07339; -; . Proteomes UP000005640; Chromosome 11; . Bgee ENSG00000117984; -; . CleanEx HS_CTSD; -; . ExpressionAtlas P07339; baseline and differential; . Genevisible P07339; HS; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; NAS:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:1904813; C:ficolin-1-rich granule lumen; TAS:Reactome; . GO GO:0043202; C:lysosomal lumen; TAS:Reactome; . GO GO:0005764; C:lysosome; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0045121; C:membrane raft; IDA:UniProtKB; . GO GO:0035580; C:specific granule lumen; TAS:Reactome; . GO GO:1904724; C:tertiary granule lumen; TAS:Reactome; . GO GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central; . GO GO:0004197; F:cysteine-type endopeptidase activity; TAS:Reactome; . GO GO:0004252; F:serine-type endopeptidase activity; TAS:Reactome; . GO GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome; . GO GO:0006914; P:autophagy; IBA:GO_Central; . GO GO:0030574; P:collagen catabolic process; TAS:Reactome; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0030163; P:protein catabolic process; IBA:GO_Central; . GO GO:0006508; P:proteolysis; IBA:GO_Central; . CDD cd05490; Cathepsin_D2; 1; . Gene3D 2.40.70.10; -; 2; . InterPro IPR001461; Aspartic_peptidase_A1; . InterPro IPR001969; Aspartic_peptidase_AS; . InterPro IPR012848; Aspartic_peptidase_N; . InterPro IPR033736; Cathepsin_chordata; . InterPro IPR033144; Cathepsin_D; . InterPro IPR033121; PEPTIDASE_A1; . InterPro IPR021109; Peptidase_aspartic_dom; . PANTHER PTHR13683; PTHR13683; 1; . PANTHER PTHR13683:SF487; PTHR13683:SF487; 1; . Pfam PF07966; A1_Propeptide; 1; . Pfam PF00026; Asp; 1; . PRINTS PR00792; PEPSIN; . SUPFAM SSF50630; SSF50630; 1; . PROSITE PS00141; ASP_PROTEASE; 2; . PROSITE PS51767; PEPTIDASE_A1; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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